![]() This microorganism infects half of the world's population and is considered as a type I carcinogen by the World Health Organization. The resulting infection may cause mild to severe complications including gastritis, peptic ulcer, gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma (MALT). pylori is a gram negative microaerophilic bacterium which inhabits the mucus layer overlying gastric epithelial cell. These results would be useful in animal model application and accounted for the development of an epitope-based vaccine against the H. ![]() Most regions of the chimeric protein were found to have a high antigenic propensity and surface accessibility. The in silico results showed that after optimizing for the purpose of expression in Escherichia coli BL21, the solubility and antigenicity of the construct fragments were highly retained. The secondary and tertiary structures of the chimeric protein and other properties such as stability, solubility and antigenicity were analyzed. ![]() pylori vaccine study, a chimeric gene containing four fragments of FliD sequence (1-600 bp), UreB (327-334 bp),VacA (744-805 bp) and CagL(51-100 bp) which have a high density of B- and T-cell epitopes was designed. In silico studies are a promising approach to design new chimeric antigen having the immunogenic potential of several antigens. Helicobacter pylori is a global health problem which has encouraged scientists to find new ways to diagnose, immunize and eradicate the H. ![]()
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